Much of the funding for autism research over the past couple of decades has gone toward identifying a genetic cause for autism. While this was a necessary step, it has yielded little fruit. To date there has not been a single autism gene discovered, or even a cluster of genes, that explain a majority of autism cases. While there may be a genetic predisposition to autism, more likely there are other cellular and environmental causes. We are particularly interested in better understanding of potential alterations and the interrelationships among them.

 

• The microbiome and microbial metabolites

• Cell metabolism and mitochondrial function

• Immune system regulation and inflammation processes

 

Emerging research suggests all of these areas may be involved in the processes of autism and the best research seeks to examine relationships among these physiological functions. Many of these areas cited above are poorly understood and their importance in disease is just beginning to come to light. It is likely that as we understand the conditions that lead to autism, we will make significant discoveries that dramatically advance our understanding of other complex, chronic diseases.