Selected Timeline of Research Beyond Genetics
1999
Small, open-label trial demonstrating improvement in children with ASD & GI issues while taking antibiotic Vancomycin
2004
Jill James documents metabolic biomarkers in children with ASD
2007
Johns Hopkins Study documents Fever Effect in children with ASD
2013
2014
Robert Nauviaux UCSD publish first results of suramin in ASD mouse model
Publication: Probiotic (B. fragilis) improves autism-like features MIA Mouse
N of One Formed
Co-sponsors 1st ever conference on ASD Microbiome
Provides Support for Mass General Sulphoraphane study
Provides funding for suramin mouse work
2016
Trial Results: Folinic Acid improves verbal communication in Children double-blind study
2019
N1 provides seed funding for BioRosa blood test for autism (7/2019)
Begin support Jun Huh at Harvard examining role of microbiome, immune system and possible links to fever effect
Trial Results: Microbioal Transplant Open label FMT Study at ASU
Publication: Probiotic (L. reuterii) restores social deficits in genetic and environmental mouse models
2021
Trial Results: Paxmedica announces postive Phase II results for suramin (Feb 2021)
2015
Publication Results: Suramin corrects deficits in FragileX mouse model
2017
Trial Results: Suramin in children (5/2017)
2020
Trial Results: Axial Phase 1b/2a trial building on insights from prior microbiome work at CalTech
2023
SFARI Organizes Global Microbiome Workshop
Paxmedica publishes results of Phase II
Very large Swedish study: Maternal and Early (child) life exposure to antibiotics increase risk of ASD & ADHD