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Selected Timeline of Research Beyond Genetics

1999

Small, open-label trial demonstrating improvement in children with ASD & GI issues while taking antibiotic Vancomycin

2004

Jill James documents metabolic biomarkers in children with ASD

2007

Johns Hopkins Study documents Fever Effect in children with ASD

2013
2014

Robert Nauviaux UCSD publish first results of suramin in ASD mouse model

Publication: Probiotic (B. fragilis) improves autism-like features  MIA Mouse

N of One Formed

Co-sponsors 1st ever conference on ASD Microbiome

Provides Support for Mass General Sulphoraphane study

Provides funding for suramin mouse work

2016

Trial Results: Folinic Acid improves verbal communication in Children double-blind study

2019

N1 provides seed funding for BioRosa blood test for autism (7/2019)

Begin support Jun Huh at Harvard examining role of microbiome, immune system and possible links to fever effect

Trial Results: Microbioal Transplant Open label FMT Study at ASU

Publication: Probiotic (L. reuterii) restores social deficits in genetic and environmental mouse models

2021

Trial Results: Paxmedica announces postive Phase II results for suramin (Feb 2021)

2015

Publication Results: Suramin corrects deficits in FragileX mouse model

2017

Trial Results: Suramin in children (5/2017)

2020

Trial Results:  Axial Phase 1b/2a trial building on insights from prior microbiome work at CalTech

2023

SFARI Organizes Global Microbiome Workshop

Paxmedica publishes results of Phase II

Very large Swedish study: Maternal and Early (child) life exposure to antibiotics increase risk of ASD & ADHD

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